CBD Oil for Depression: Does it Work?

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depressed woman in bed

With cannabidiol (CBD) popping up everywhere, the consumer demand for CBD oil for depression and anxiety is high and growing. With fewer side effects in most people, studies show that it may be an effective option to treat various mental illnesses or mood disorders such as depression.

For those who have been self-medicating for years, the potential of CBD as a powerful antidepressant could prove to work. Although clinical trials are limited, there’s good evidence that CBD could help you recover from anxiety or depression.

If you’re considering to try CBD products and want to learn about the current scientific research and its link to curing depression, then keep on reading!

What is Depression?

First off, let’s discuss depression.

Negative self-image, having trouble doing normal daily activities, feeling down, sadness, are all symptoms of depression. Sometimes, it makes you think that life isn’t worth living.

It also comes with mental problems like the reduced ability to think clearly as well as a lack of concentration. These are just some of the symptoms of depressive disorder or clinical depression.

It’s a serious medical condition that affects how you behave, feel, and think. You feel stuck. As if you can’t do anything about it. This can harm your body, mind, and overall well-being. 

Common treatments for depression include selective serotonin reuptake inhibitors (SSRIs), psychotherapy, support groups, brain stimulation therapy like Electroconvulsive Therapy (ECT), Repetitive Transcranial Magnetic Stimulation (rTMS), and Vagus Nerve Stimulation (VNS).

However, CBD oil for depression is becoming popular for a growing number of people who are interested in the treatment of anxiety and depression in a more natural way.

What the Research Says About CBD Oil for Depression

There are a number of studies explaining why CBD could be a possible solution in treating depression. One of the top reasons why depression sufferers chose CBD is due to its lessened side effects in comparison to prescribed pharmaceutical drugs.

This alternative form of treatment offers relaxation that doesn’t cause a euphoric high but can still influence your mood and cognitive mental processes in positive, powerful ways.

According to studies, CBD helps protect and grow neurons. They indicate that CBD does help to have a positive engagement with serotonin receptors in the brain. Although research on CBD in human patients is lacking, some preliminary studies are promising.

Scientists found that CBD acted like anti-stress and antidepressant in rodent models. The exhibits showed that after a short or long-term use of CBD, it helped relieve depression and eases pain in rodent models. The scientists also indicate that there’s a low chance that CBD will become addictive. This is crucial since some people are wondering if CBD is mind-altering or habit-forming medication.

Researchers also did some human clinical trials and found some positive results for panic disorder and anxiety. In their studies, it showed that a single dose of CBD 300 milligrams (mg) minimized the level of anxiety for healthy volunteers after the test. Needless to say, the importance of CBD for people with panic disorder caught the attention of scientists.

Ways of Consuming CBD Oil for Depression


  • Ingest it orally – For beginners, we recommend to take your CBD orally. Just like other prescription drugs, you can take it in the form of pills or gummies. If you don’t mind the taste of the oil, you can just take the oil straight up. Please note that it will take longer to feel the effect since your body has to digest it. Normally, it will kick in at about one to two hours after administration.
  • Topical application – There are CBD products like ointment, beauty cream, lotion, body scrub, and lip balm. This is a great choice for pain-relief, stiffness, or inflammation of specific body parts. Apply a liberal amount of CBD to your skin to experience the effects.
  • Inhalation – If you want the immediate effect of CBD, then you should inhale it by vaping or smoking. There are many options available for oils that can be vaped, or high-CBD strains that you smoke, just make sure you research and get a good one! Inhaling CBD has a quick effect because the cannabidiols will enter your bloodstream almost immediately.

Potential Side Effects of Taking CBD Oil for Depression

Until now, there is no proof that CBD is addictive or dangerous. No matter how you use it; sublingual, topically, or by inhaling it, there is a minimum number of side effects of CBD.

Though CBD is safe, it may cause adverse reactions if someone is sensitive to the compounds in CBD.

The following side effects were noted in the studies with dosages above 1500mg per day. Therefore, it is reasonable to conclude that at a normal dosage of 10-20mg per day, CBD is completely safe.

  • Diarrhea
  • Changes in appetite
  • Fatigue
  • Changes in sleep
  • Nausea
  • Weakness
  • Malaise
  • Liver stress

Before you start taking CBD, it’s smart to ask your doctor to avoid possible harmful interactions with several medications.

How to Use CBD Oil for Depression

man sitting in hallway

It’s important to buy only reputable products because the Food and Drug Administration (FDA) doesn’t regulate natural supplements like CBD.

Start Low

Read the label on the packaging and start with the lowest recommended dose. Over time, you can work your way up slowly from there. As a general rule, only take when needed to produce an effect.

Seek Professional Help

If you’re really depressed and experiencing thoughts of suicide, seek the advice of a medical professional. They will provide guidance and monitor your progress once you take CBD products.

Keep a Journal

It’s important to be mindful when using CBD. To find out if the supplement is working for you, it’s a good idea if you keep track of the changes. Here are some items you should record when filling out your journal:

  1. Write the date and the severity of your depression.
  2. The type of CBD product and the dosage.
  3. Side effects like fatigue, diarrhea, or change in appetite.
  4. Other medications you’re taking.

It takes time, patience, and love to treat depression. Although CBD can help to grow and form a new engagement with serotonin in your brain, you’re still in charge of how you’re gonna react to your situation.

If you combine psychotherapy, workout, self-help books, or sometimes pets, you can help your brain move in a more loving direction. Also, if you take prescription drugs, don’t forget to talk to your doctor before adding CBD into your medication routine. Do NOT simply stop taking your meds and replace them with CBD! 


  • https://www.ncbi.nlm.nih.gov/pubmed/24923339
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908414/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412699/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189631/

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