Proin for Dogs: What Phenylpropanolamine Can Do for Your Pup!

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By: CertaPet Staff Updated: June 15, 2020

Proin for Dogs: What Phenylpropanolamine Can Do for Your Pup! Created and manufactured by PRN Pharmacal, Proin is a prescription-only supplement specifically for dogs that aids in the management and symptom relief of urinary incontinence.

With the generic name of phenylpropanolamine, Proin is sometimes manufactured under the name Propalin in Europe and other parts of the world.

Proin comes in the form of liver flavored chewable tablets that even the fussiest dogs enjoy.

Proin for Dogs: Why Would A Dog Need it?

Dogs of all ages and all breeds can display signs of urinary incontinence. Urinary incontinence and other bladder problems can be frustrating and disheartening for dog owners to deal with.

Fortunately, Proin is a supplement that can aid in relieving the symptoms of urinary incontinence in dogs.

Puppy sitting on a carpet with wet spot, proin for dogs

If your dog is displaying any of the following symptoms, book an appointment with your veterinarian to discuss a possible diagnosis of urinary incontinence:

  • Urinating in the house or in sleeping areas
  • Leaking or dripping urine
  • Urinating while sleeping
  • Frequent urination
  • Excessive licking or cleaning of the genital area
  • Genital area appearing irritated and red

If any of these symptoms are plaguing your dog, don’t delay before seeking medical attention.

Urinary incontinence is easily treatable with Proin, so there is no need to you to put up with the debilitating symptoms any longer.

Did you know that urinary incontinence can sometimes be caused by UTIs or kidney disease. Check out our articles on UTI In Dogs and Kidney Disease In Dogs for more information.

How Does Proin Work?

The active ingredient in Proin is phenylpropanolamine hydrochloride, which is an adrenergic agent that assists in the tightening of the muscles of the bladder sphincter, effectively controlling bladder leakage and other symptoms of urinary incontinence.

High levels of phenylpropanolamine in a dog’s bloodstream have been associated with undesirable side-effects including:

  • high blood pressure
  • hyperexcitability
  • increased heart rate, and
  • decreased appetite

In order to combat these potential side-effects, Proin enables a sustained release of its active ingredient, ensuring that the levels of phenylpropanolamine in a dog’s bloodstream are controlled and sustained – greatly reducing the risk of symptoms associated with high levels of phenylpropanolamine.

Proin Ingredients

The active ingredient in Proin is phenylpropanolamine hydrochloride. The tablets are in chewable form and are liver flavored, making it easier to administer the supplement to dogs.

Proin 50 MG and On Chewable Tablets: Proin Dosage for Dogs

The Proin dosage for dogs is calculated according to the dog’s body weight. The usual dosage is between 0.4 and 0.8 mg per pound of body weight, administered every 12 hours. However, your veterinarian will advise you the exact dosage to give your dog.

Proin is available in three different strengths: 25 mg, 50 mg, and 75 mg. All three strengths come in chewable tablet form, all are scored down the middle for easy splitting, and all are liver flavored to appeal to a dog’s taste buds.

Note that, as with most medications and other products, it is cheaper to buy in bulk. For example, if your dog requires the 25 mg strength tablet, it is perfectly acceptable to buy the 50 mg chewable tablets and split each tablet in half—but make sure you consult your vet before you do this!

Proin Chewable Tablets for Dogs
Proin is a chewable tablet prescribed by your veterinarian to treat and manage urinary incontinence in dogs. It works by helping to tighten the bladder and urethral muscles to prevent urine leaking and accidents. Best of all, it comes in a tablet, so you can feed it to your pet by mouth or disguise it inside a tasty pill pocket.
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Proin 50mg

The medium-size dosage, Proin 50 mg tablets come in a choice of 60 or 180 chewable tablets per bottle. Each tablet is scored down the middle to enable them to be split in half with ease. The active ingredient is 50 mg of phenylpropanolamine.

Proin 25 mg

The Proin 25 mg tablet is the lowest strength dosage available, and consists of 25 mg of the active ingredient, phenylpropanolamine. 25 mg Proin tablets come in bottles of 60 or 180 tablets, and all are scored down the middle to allow easy splitting.

Proin 75 mg

The highest strength Proin tablet available, Proin 75 mg tablets are made up of 75 mg of the active ingredient, phenylpropanolamine, and are sold in bottles of 60 tablets only.

75 mg Proin tablets are liver flavored and chewable, allowing for easy feeding to your dog. Note that 75 mg Proin tablets are not available in bottles of 180 chewable tablets, unlike the lower strength 25 mg and 50 mg varieties of this medication.

Possible Proin Side Effects in Dogs

Like all medications, Proin and phenylpropanolamine hydrochloride can cause a number of side-effects. When giving a new medication to your dog, be vigilant and make note of any changes in your dog’s appearance or behavior.

Side-effects of Proin are rare, but some can be dangerous or even life-threatening. Monitor your dog carefully when giving Proin or any other prescription medication or supplement and contact your veterinarian if you notice any changes in your dog, no matter how minor they may seem at the time.

Proin can cause an allergic reaction in some dogs. Symptoms of an allergic reaction can include:

  • hives
  • swelling of the face, tongue, or the lips, and/or
  • breathing difficulties.

If you notice any of these side-effects in your dog after administering Proin, do not give any further doses and contact your veterinarian immediately.

Proin can also cause a number of other less serious side-effects, including:

  • loss of appetite
  • irritability
  • restlessness
  • increased blood pressure, and/or
  • increased heart rate.

If your dog displays any of these less serious side-effects of Proin, continue to administer the medication but also contact your veterinarian as soon as possible to let them know of your concerns.

More serious side-effects of Proin can include:

  • tremors or seizures
  • kidney failure
  • urine retention
  • blood in urine
  • vomiting
  • confusion
  • diarrhea
  • fever
  • weakness
  • change in skin color, and/or
  • abnormal gait.

If your dog shows signs of any of these side-effects, do not give any further doses of Proin and contact your veterinarian as soon as possible.

Proin for Dogs Overdose: What to Look For

Proin tablets are chewable and liver flavored, making it easy to administer to dogs as dogs see them as little more than a tasty treat.

Unfortunately, this can cause problems if dogs gain access to the bottle of chewable tablets.

Unfortunately, even sealed bottles of Proin are far from dog proof, as proven by previously reported incidents of dogs chewing through closed bottles and eating the contents.

As with all medications, ensure that any unused tablets are kept well out of reach of pets and children alike. If you suspect that your dog has overdosed on Proin, seek medical help urgently.

A mild overdose is likely to cause little more than an increased chance of the medication’s regular side-effects, however, large overdoses can be significantly more severe, and can cause heart problems, hypertension, Creutzfeldt-Jakob disease, Cushing’s disease, or could even put your pet into a coma.

Proin Alternatives? How Else Can You Help Your Dog’s Urinary Incontinence

With Proin being a prescription only dog medication, alternatives can be found in your local natural health store.

Proin works by strengthening the muscles of the urethral sphincter, and there are a number of natural and herbal products that claim to have the same effect.

Uva ursi bearberry plant with red fruits, proin alternative

Your local natural health practitioner may suggest herbs such as:

  • plantain
  • raspberry leaf
  • uva ursi, or
  • oestrogenic compounds or a traditional Chinese medicine formulation.

If your dog’s urinary incontinence is mild and not causing too much inconvenience to you or discomfort to your dog, it can be worth pursuing Proin alternatives.

PetHonesty Cranberry UTI Strength Snacks Urinary Tract Soft Chews
Help support your furry friend’s urinary and bladder health with PetHonesty’s Cranberry UTI Strength Snack!! This supplement is made with a wag-worthy natural chicken flavor and a powerful combination of cranberry and marshmallow root. Together, these ingredients help reduce UTIs and bladder infections, encourage normal pH levels and ideal bladder function, and also help eliminate toxin build-up which can lead to painful urinary problems. Not only do these supplement snacks help support your pet’s urinary health, but they are also completely free of GMOs, wheat, corn, soy and preservatives, for a chew you can feel good about choosing for your canine companion.
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On the other hand, if your dog’s urinary incontinence is causing major problems in your household, speak to your veterinarian about starting on Proin as soon as possible.

Doggie Dailies Glucosamine for Dogs
Doggie Dailies is a highly effective hip and joint soft chew your dog will love. Our glucosamine dog treats are specially formulated to promote healthy joints, improve mobility, and ease discomfort from hip dysplasia and painful arthritis. A daily dose of Doggie Dailies soft chews will help improve your dog’s mobility and overall joint health allowing them to live a happier, healthier life.
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Proin Reviews: What’s the Consensus?

In general, consumer reviews for Proin are largely positive. Some people claim that chewable Proin cured their dog of symptoms of urinary incontinence after other remedies were unsuccessful.

Many Proin reviews refer to older dogs having problems with urinary incontinence, with most of the affected dogs being female.

Some reviewers note that they administer Proin in conjunction with herbal supplements to keep their dog’s urinary tract incontinence symptoms at bay.

3 Things You Need to Know Before administering Proin to Your Dog

  1. Before starting your dog on any new medication, it is vital that you update your veterinarian with your dog’s full medical history. In particular, ensure that your veterinarian knows of any previous allergic reactions that your dog has had to this or any other medication, as well as any other existing medical conditions or symptoms. For female dogs, advise your vet if your dog may be pregnant or is currently lactating.
  2. One of the more common side effects of Proin is high blood pressure, so keep this in mind before giving Proin to your dog. Your veterinarian will need to know if your dog has ever suffered from other blood pressure disorders, other ailments like diabetes, or any kind of kidney or liver conditions.
  3. Proin should never be given to a dog who is currently taking or has taken within the previous two weeks, a Preventic Collar, selegiline, Anipryl, MAOi, epinephrine, or ephedrine. These medications and treatments should never be taken together, as severe side effects could occur.

Proin Cost! Can You Buy Proin Online?

Proin can be purchased online from several pet supplier websites. However, keep in mind that Proin is a prescription only medication, so you will need to provide a prescription from your veterinarian when placing your order online.

In addition, Proin cannot be shipped to Oregon, Iowa, Louisiana, or Arkansas as it is considered a controlled substance in those states. Similarly, Proin cannot be shipped overseas from United States based websites.

The cost of 60 chewable tablets at the lowest dose of 25 mg will range from $12 to $18, while at the larger end the cost of 60 chewable tablets at 75 mg will range between $21 and $27.

3 Tips for Giving Your Hurting Pup Proin

  1. If you miss giving your dog a regular dose of Proin, administer the missed dose later the same day. However, do not make up a missed dose the following day, and never provide a double dose under any circumstances.
  2. Proin is sold in a liver flavored chewable tablet, so tell your dog that you are giving them a treat rather than medication. Your pup will be much more likely to happily take their regular dose of Proin if it is given with enthusiasm and praise like any other treat.
  3. Bottles of Proin are far from dog proof, so ensure that the bottle containing unused Proin tablets is stored in an area that your dog and other pets cannot access. Dogs have been known to chew through sealed bottles of Proin to get to the liver flavored tablets inside, so don’t run the risk of having your dog overdose on their medication.

Help Your Dog’s Urinary Health with Proin!

If your dog is suffering from urinary tract incontinence, consider trialing your dog with Proin. Your veterinarian will be able to provide a prescription for the medication and will let you know the exact dosage to administer, based on the size and weight of your dog.

Not only does Proin have excellent consumer reviews, it is currently the only urinary incontinence medication that works by tightening the muscles of the urinary sphincter that has been approved by the FDA.

No dog should have to suffer from urinary incontinence. By administering Proin to your dog, you can put an end to the symptoms of incontinence and bladder leakage, saving yourself the embarrassment and your dog the discomfort associated with urinary tract health problems.

Common Questions On Proin

What are the side effects of phenylpropanolamine?
What is phenylpropanolamine hydrochloride used for?
How long does it take for Proin to work?

Disclaimer: This post may contain references to products from one or more of our partnered sites, Honest Paws and Vets Preferred. However, CertaPet content is to be used for educational and informational purposes only. Please seek veterinary advice for your own situation. For more on our terms of use, visit this page

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